Multilocular cystic renal neoplasm of low malignant potential:A clinicopathological analysis
WANG Han
ZHAO Dachun
WANG Feng
GUO Pingping
NI Mazhuoma
DA Zhen
WANG Qian
DUO Bula
LUO Hanhuan
Abstract：Objective To analyze the clinicopathological characteristics,diagnostic criteria,and differential diagnosis strategies of multilocular cystic renal neoplasm of low malignant potential(MCRNLMP).Methods A retrospective analysis of clinicopathological features and immunophenotypes was conducted in 6 cases of MCRNLMP,supplemented by a review of relevant literature.Results Among the 6 MCRNLMP cases,the patients'ages ranged from 35 to 65 years(mean age:50.17±10.89 years),and tumor diameters ranged from 6 to 8 cm(mean diameter:6.50±0.84 cm).Gross examination revealed well-circumscribed multilocular cystic masses containing small amounts of pale yellow or dark brown fluid.Microscopically,the tumors were cystic,lined by a single layer of clear cells with occasional stratified epithelium and minimal nuclear atypia.Immunophenotypically,all 6 cases showed variable expression of PAX-8,carbonic anhydrase IX(CAIX),EMA,CK7,and CD10,while CD68 and CD117 were negative.The Ki-67 proliferation index ranged from 1%to 3%.During follow-up(16-42 months),no recurrence or metastasis was observed.Conclusion MCRNLMP is a rare renal tumor with favorable prognosis.Preoperative diagnosis is challenging,and definitive diagnosis relies on postoperative pathology.It must be differentiated from cystic renal cell carcinoma and benign renal cystic lesions,with immunohistochemical staining aiding in differential diagnosis.
Keywords：renal neoplasmsmultilocular cystic renal neoplasm of low malignant potentialpathological featuresdiagnosisdifferential diagnosis
Publication Date：2025-11-28
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：5( 1426-1430 )