Invasive breast carcinoma with medullary features:a clinicopathological and molecular analysis of nine cases
LIU Ye
WANG Wenwen
REN Lei
LI Li
JIANG Hongmei
LI Kuifang
Abstract：Objective To investigate the clinicopathologic characteristics,immunophenotype,differential diagnosis,and molecular features of breast carcinoma with medullary features(CMF).Methods Clinical and pathological data of 9 cases of breast CMF treated at Jiangyin Traditional Chinese Medicine Hospital from 2015 to 2022 were collected.Immunohistochemical staining,in situ hybridization(ISH)detection for Epstein-Barr virus(EBV),and next-generation sequencing(NGS)were performed,and relevant literature was reviewed.Results The patients were aged 37 to 75 years(median age:53 years).Morphologically,the tumors presented as syncytial cell clusters with a pushing growth pattern,indistinct cell borders,cellular atypia,high-grade nuclei,and prominent lymphocytic infiltration.Immunophenotypically,estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER2)were negative.The Ki-67 proliferation index ranged from 60%to 90%.Basal cell markers were expressed,and p53 showed mutant-type expression.Molecular testing of 3 cases showed TP53 gene mutations,while ISH for EBER yielded negative results.Conclusion Breast CMF is a high-grade breast carcinoma of no special type with TP53 mutations.It belongs to the immunomodulatory subtype of triple-negative breast cancer,is not EBV-associated,and has a relatively favorable prognosis..
Keywords：Medullary featuresTriple-negative breast cancerClinical pathologyImmunohistochemistryNext-generation sequencing
Publication Date：2025-10-28
Online Publishing Date：2025-11-06(First online date of this platform, not the publication date of the document)
Pages：5( 1238-1242 )