Low-grade serous cystadenocarcinoma of the testis:reportof a case and review of literature
DENG Dan
LI Xiaomei
MA Li
JI Xingli
CAO Xuefeng
LONG Yitian
YANG Fan
Abstract：Objective To discuss the etiology, pathological diagnosis, differential diagnosis, and treatment of testicular low-grade serous carcinoma. Methods A retrospective analysis was conducted on the medical history, symptoms, imaging data, and pathological diagnosis of a case of testicular low-grade serous adenocarcinoma diagnosed by the pathology department of Chengdu Fifth People's Hospital. Related literature was reviewed and analyzed. Results The patient was a 39-year-old male who had been found with a right scrotal mass for more than 10 years. Ultrasound showed a solid mass in the right scrotum. Grossly, the testis presented as a cystic-solid mass. Routine immunohistochemical staining showed that the tumor cells expressed SOX-10, WT-1, CK7, and CA125 (+). Molecular pathology testing revealed TERT C124T mutation, BRAF V600E mutation, and MET gene amplification. Conclusion Testicular low-grade serous tumors are rare ovarian epithelial-type tumors of the testis. Their imaging features are not specific. Histological morphology, immunohistochemical expression, and molecular pathological changes are consistent with low-grade serous tumors of the ovary. In male patients with testicular tumors, high vigilance is required, and differential diagnosis should be made with yolk sac tumor, mesothelioma, etc.
Keywords：TestisSerous AdenocarcinomaImmunohistochemistryCase Report
Publication Date：2025-09-28
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：4( 1175-1177,1217 )