Angiomatoid fibrous histiocytoma:a clinicopathological analysis of four cases and review of literature
ZHANG Zilan
XIAO Qin
MAO Leilei
WANG Cuimei
YANG Xi
Abstract：Objective To explore the clinicopathological features and immunophenotypes of angiomatoid fibrous histiocytoma(AFH),aimed to provide a basis for its diagnosis and differential diagnosis.Methods The clinical and pathological data of four cases of AFH at Northern Jiangsu People's Hospital from 2012 to 2024 were retrospectively analyzed.Relevant literatures were reviewed.Results Pathologically,the tumor had a clear boundary,with surrounding lymphoid tissue visible.Tumor cells were arranged in nodular or nest-like patterns,and the tumor contained irregular hemorrhagic cystic cavities.Immunohistochemically,the tumour cells were positive for EMA,CD99,and Desmin.Fluorescence in situ hybridization(FISH)detection confirmed the presence of EWSRl gene split signals in all 4 cases.Conclusion AFH is a rare intermediate soft tissue tumor.Accurate diagnosis can be achieved by combining histopathological findings with related examinations,which provides a basis for clinical treatment.
Keywords：Soft tissue tumorAngiomatoid fibrous histiocytomaPathological diagnosisDifferential diagnosisClinical prognosis
Publication Date：2025-09-28
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：4( 1142-1145 )