Corded and hyalinized endometrioid carcinoma:clinicopathological and molecular features of five cases
LIU Hangqi
WANG Juan
ZHOU Yang
CAI Yumeng
PANG Junyi
CHEN Longyun
SHI Xiaohua
Abstract：Objective To investigate the histopathological features,immunophenotype,differential diagnosis,molecular subtypes,and genetic variation characteristics of corded and hyalinized endometrioid carcinoma(CHEC).Methods The clinicopathological data of 5 cases of CHEC were retrospectively analyzed,supplemented by immunohistochemical staining and molecular pathological detection.A systematic review of relevant literature was conducted.Results The cohort had a mean age of 36 years,with tumors classified as FIGO stage IA(n=1),IB(n=2),and Ⅲ A(n=2).The mean follow-up time was 16 months,with all patients remaining disease-free.Histologically,tumors exhibited a biphasic morphology:conventional endometrioid carcinoma intermingled with infiltrative epithelioid-to-spindled cells embedded in hyalinized stroma.Tumor cells demonstrated mild-to-moderate nuclear atypia,with low proliferative activity(mean mitotic count:1.6/10 HPF;wild-type p53 expression;low Ki-67 proliferation index).Molecular subtyping revealed that the majority were of the NSMP type(4/5,80％),and one case was of the p53-mutant type(1/5,20％).Common genetic mutations included CTNNB1(4/4),ARID1A(3/4),PTEN(3/4),and PIK3CA(2/4).Conclusion CHEC represents a distinct and rare subtype of endometrioid carcinoma,and TCGA-based subtyping has important clinical value in this tumor.High-frequency CTNNB1 mutation is one of its characteristics and serves as a high-risk stratification factor in the NSMP subtype.
Keywords：Corded and hyalinizedEndometrioid carcinomaMolecular subtypeGenetic variation
Publication Date：2025-09-28
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：7( 1131-1136,1141 )