Expression of IL28RA in esophageal cancer tissue and its clinical significance
PAN Fanfan
WANG Wei
PAN Chunsheng
Abstract：Objective To investigate the expression of interleukin-28 receptor α(IL28RA)in esophageal carcinoma and its clinical significance.Methods Clinical data of 146 patients who underwent radical resection for esophageal carcinoma from April 2015 to May 2020 were retrospectively analyzed,with a 3-year postoperative follow-up.The expression of IL28RA in cancer tissues and adjacent tissues of all patients was detected.The correlation of IL28RA expression with clinicopathological characteristics,postoperative recurrence,and metastasis was analyzed.Results The positive expression rate of IL28RA protein in cancer tissues was lower than that in adjacent tissues(P＜0.05).The positive expression rate of IL28RA protein was lower in poorly differentiation,stage Ⅲ,and lymph node metastatic cancer tissues than in moderately/well-differentiated,stage Ⅱ,and no lymph node metastatic cancer tissues(P＜0.05).Cox regression analysis showed that pathological stage(RR=6.482,95CI％:2.667-15.753),differentiation degree(RR=4.968,95％CI:2.044-12.074),and positive IL28RA protein expression(RR=0.409,95CI％:0.168-00.994)were factors affecting postoperative recurrence and metastasis in patients with esophageal cancer(P＜0.05).The disease-free survival of patients with positive expression of IL28RA protein was better than that of patients with negative expression(P＜0.05).Conclusion IL28RA is lowly expressed in esophageal cancer tissues.Patients with positive IL28RA protein have a lower risk of postoperative recurrence and metastasis.
Keywords：Esophageal cancerInterleukin-28 receptor αClinicalpathologyTissue expression
Publication Date：2025-09-28
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：5( 1085-1089 )