Clinicopathological and molecular features of breast mucinous carcinomat:report of ten cases
LIU Ye
WANG Wenwen
BAO Shuyou
JIANG Dongdong
CHEN Ji
LI Li
LI Kuifang
Abstract：Objective To investigate the clinicopathological features,immunophenotype,differential diagnosis,molecular features of breast mucinous carcinoma.Methods A total of 10 cases of breast mucinous carcinoma were collected from our pathology department between 2015 and 2024.These cases were analyzed using immunohistochemical staining,fluorescence in-situ hybridization and next-generation sequencing,as well as reviewing related literatures.Results The 10 cases were female with age range of 43-84 years(mean 61.5 years).Histologically,the cases exhibited distinct features such as clusters,glandular,trabecular,cribriform,papillary,micropapillary,and nest-like structures in extracellular mucus,with mucus component accounting for 60％-90％(more than 90％)of the total.Immunophenotypically,ER was positive(10/10),PR positive(7/10),HER2 negative(9/10),and Ki-67 index ≤ 20％(8/10);Molecular features included GATA3 shifted code mutation,ERBB2 and MDM2 copy number variation,MET missense mutation,but no common mutations of breast carcinoma(PIK3CA,TP53,BRAC1/2)were identified.Conclusion Breast mucinous carcinoma lacks the high-frequency PIK3CA mutations typically associated with hormone receptor-dependent breast carcinoma,indicating potential clinical significance of other mutations such as GATA3 and MET etc.More cases may warrant further investigation into these molecular features.
Keywords：Mucinous carcinoma of the breastHormone receptor dependenceClinical pathologyImmunophenotypeMolecular features
Publication Date：2025-08-28
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：6( 973-978 )