Clinicopathological features of the acquired cystic disease-associated renal cell carcinomas
PAN Yi
PANG Yaqing
FANG Wei
Abstract：Objective To investigate the clinicopathological features,immune phenotype,molecular characteristics,diagnosis and differential diagnosis of acquired cystic disease-associated renal cell carcinomas(ACD-RCC).Methods The clinical and pathological characteristics were analyzed in four cases of ACD-RCC,and the relevant literature was reviewed.Results All the 4 patients were male and three of them had a history of hemodialysis or peritoneal dialysis.The mass had a cystic or solid structure.It is characterized most often by microcystic or cribriform architecture,eosinophilic cells,and intratumoral calcium oxalate crystals deposition.Immunohistochemistry showed positivity for PAX-8,Pax-2,RCC,p504s,CD10,vimentin,CA Ⅸ,CK7(1/4),CD117(1/4),and negative for TFE-3.Ki-67 proliferation index was approximately 1％～5％.FISH of chromosome 17 showed monosomy for one case,combined deletion of chromosomes 3,7,17 for one case,and one case was detected with chromosome Y deletion.Conclusion ACD-RCC is relatively rare and often occurs in end-stage renal failure or dialysis patients,exhibiting characteristic histopathological features.ACD-RCC lacks specific or defining molecular alteration,and the prognosis is good.
Keywords：End-stage renal diseaseAcquired cystic kidney diseaseRenal cell carcinoma
Publication Date：2025-08-28
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：5( 947-951 )