Expression of CyclinD1,GPR27 and SETDB1 in breast cancer tissues and their relationship with prognosis

CHEN Jia-jing; LIN Hui; XUE Li-qiu

doi:10.3969/j.issn.1007-8096.2025.06.008

Abstract：Objective To explore the expression of CyclinD1,GPR27 and SETDB1 in breast cancer tissues and their relationship with prognosis.Methods A total of 110 paraffin-embedded tissue specimens from patients with breast cancer who were pathologically diagnosed from May 2017 to May 2021 were selected.The expression levels of CyclinD1,GPR27 and SETDB1 in breast cancer tissues and adjacent tissues were detected by immunohistochemistry.The patients were divided into high and low groups based on the expression level,and the relationships with clinicopathological features and 3-year Relapse free survival(RFS)were analyzed.Results The high expression rate of CyclinD1 in breast cancer tissues was61.82%(68/110 cases)compared with12.73%(14/110 cases)in adjacent tissues(x2=56.691,P＜0.05).The high expression rate of GPR27 in breast cancer tissues was 77.27%(85/110 cases)compared with 21.82%(24/110 cases)in adjacent tissues(x2=67.661,P＜0.05).The high expression rate of SETDB1 in breast cancer tissues was 65.45%(72/110 cases)compared with 29.10%(32/110 cases)in adjacent tissues(x2=29.181,P＜0.05).There were no differences in the expression of CyclinD1 among age,body mass index,disease site,tumor diameter,lymph node metastasis,PR,HER2 and molecular typing groups(P＞0.05),but it was correlated with TNM stage,tumor differentiation and ER(P＜0.05).There were no differences in the expression of GPR27 among age,body mass index,disease site,tumor diameter,ER,PR,HER2 and molecular typing groups(P＞0.05),but it was correlated with TNM stage,tumor differentiation and lymph node metastasis(P＜0.05).There were no differences in SETDB1 expression among age,body mass index,disease site,tumor diameter,PR,HER2 and molecular typing groups(P＞0.05).It was associated with TNM stage,tumor differentiation,lymph node metastasis and ER(P＜0.05).There was positive correlation among CyclinD1,GPR27 and SETDB in breast cancer patients(P＜0.05).The 3-year probability of RFS in patients with high and low expression of CyclinD1 was 82.35%and 95.24%,respectively.The 3-year probability of RFS in patients with high and low expression of GPR27 was 85.88%and 92.00%,respectively.The 3-year probability of RFS in patients with low and high SETDB1 expression was 97.37%and 81.94%,respectively.The 3-year RFS rates of CyclinD1,GPR27,and SETDB1 high expression groups were lower than those of low expression groups(P＜0.05).Conclusion CyclinD1,GPR27 and SETDB1 are highly expressed in breast cancer tissues,which is related to clinicopathology and survival.