Hepatoid adenocarcinoma of the pancreas:report of a case and review of literature
WU Yue
GUO Shu-jing
LIN Mei-fang
LIN Feng-lian
CHANG Wen-jing
XU Ran-ran
YU Ya-qi
DING Xin
Abstract：Objective To explore the clinical and pathological characteristics of pancreatic hepatoid adenocarcinoma (PHC). Methods A retrospective analysis of the clinical and pathological data of one patient with PHC was conducted, and relevant literature was reviewed. Results The patient was a 59-year-old male. Ultrasound and CT of the liver, biliary tract, and pancreas showed a mass lesion in the tail of the pancreas. MRI suggested a possible pancreatic neuroendocrine tumor. Tumor markers AFP, CEA, CA199, and CA125 were all normal. The liver had a normal shape and size, smooth surface, and normal lobe proportions. No abnormal signals were seen in the hepatic parenchyma. Under the microscope: the tumor cells were arranged in nests, trabecular, and fascicular patterns, with fibrous septa, invading the spleen tissue. The cells were polygonal or spindle-shaped, with abundant cytoplasm and eosinophilic staining. The nuclei had irregular membranes, with obvious nucleoli, and some had nuclear inclusions and multinucleated giant tumor cells. Some showed eosinophilic bodies, with a large number of vascular and neural invasion. Immunophenotype: positive: CK-P, Hepar-1 (focal +), GPC-3, CD10, GS-6 (diffuse +), CK18 (weak +), CK19 (scattered +), β-Catenin (membranous +), CD117 (scattered +), Ki-67 (+, about 3%). Negative: Arginase-1, SALL4, Vimentin, CK7, CEA, CK20, Villin, CDX2, CD56, CgA, SYN, S-100, CD34, PAX-8, CK5/6, p40, ALK (D5F3), HMB45, Ksp-Cad, EMA. Conclusion PHC is a rare primary pancreatic tumor, and early surgery and long-term follow-up are crucial for prognosis.
Keywords：Pancreatic tumorHepatoid adenocarcinomaClinical and pathological featuresImmunohistochemistry
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 584-586 )