Clinical and pathological features of ESD rectal neuroendocrine tumor:report of a case
ZHANG Feng-mei
LI Yun
ZHU Ya-qing
Abstract：Objective To analyze the clinical and pathological features of a case of rectal neuroendocrine tumor (NET), and to explore the diagnostic and treatment points. Methods A 64-year-old female patient was admitted with a rectal elevated lesion, and underwent endoscopic submucosal dissection (ESD). Postoperative specimens were stained with HE and immunohistochemistry, and were stained with multiple antibodies such as Synaptophysin, CD56, and Chromogranin A. The results were independently evaluated by two pathologists. Results The resected specimen showed that the tumor mainly located in the mucosa and submucosa, with cells arranged in nests, cords, and glandular patterns. The cell nuclei were round and regular, and red granules were seen in the cytoplasm. Immunohistochemical results showed positivity for Synaptophysin and CD56, with a Ki-67 proliferation index of 2%, supporting the neuroendocrine differentiation characteristics. According to the 2022 diagnostic criteria, the tumor was diagnosed as G1 stage neuroendocrine tumor. The patient recovered smoothly after surgery, and no recurrence or metastasis was observed during the 6-month follow-up. Conclusion Rectal neuroendocrine tumors have an insidious course, and diagnosis relies on pathological and immunohistochemical results. Early diagnosis and treatment are crucial for improving patient prognosis. ESD is an effective treatment for NETs without metastatic risk, and the application of endoscopic examination in tumor screening should be strengthened. Multidisciplinary diagnosis and treatment strategies should be optimized.
Keywords：Rectal neuroendocrine tumorEndoscopic submucosal dissectionPathological featuresImmunohistochemistryEarly diagnosis
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 580-583 )