Cytomorphological characteristics of intrathyroid thymic carcinoma with fine-needle aspiration
TANG Yong-fa
TANG Fu-ting
Abstract：Objective To investigate the fine needle aspiration cytology(FNAC)characteristics of intrathyroid thymic carcinoma(ITTC).Methods The clinical data,FNAC features,histological features,immunophenotype and BRAF V600E gene detection results of a patient diagnosed with ITTC were retrospectively analyzed,and relevant literature was reviewed.Results The patient was a 70-year-old woman;the tumor was located in the lower part of the left thyroid lobe,with a maximum diameter of 15 mm.Features of FNAC:The tumor appeared as large cell clusters and individual cells;the nuclei of the tumor cells were crowded,round,finely granular,moderately hyperchromatic,mild-moderately enlarged and atypia,and slightly thickened nuclear membrane;small nucleoli could be seen;the tumor cytoplasm was scarce with indistinct border and high nuclear-to-cytoplasmic ratio.The cytological diagnosis was epithelial tumor,suspected to be malignant.Postoperative tumor tissue positively expressed CD5,CD117,p40,Cyclin D1,CK5/6,Calectin-3,and p53 mutants,and a small amount of tumor cells expressed CgA,Syn,and HBME-1.Histological diagnosis was ITTC.BRAF V600E gene detection was wild type.Conclusion ITTC is a rare tumor.It is important for differentiating ITTC between similar tumors with poor prognosis by cytology to know the FNAC characteristics of ITTC,and avoiding excessive preoperative treatment.
Keywords：Intrathyroid thymic carcinomaCytologyFine needle aspiration
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 569-573 )