ALK-rearranged spindle cell neoplasm:a clinicopathologic analysis of a case
ZHANG Ying
LI Jing
XIAO Gao-fang
YANG Shu-hui
TAN Cai-yun
DU Ri-chang
Abstract：Objective To investigate the clinicopathological characteristics,diagnosis,and differential diagnosis of ALK-rearranged spindle cell tumor.Methods The clinical,imaging,and pathological features of one case of ALK-rearranged spindle cell tumor were observed and analyzed,along with a review of the literature.Results A 50-year-old female patient presented with a left axillary mass for over 10 days.Microscopically,mucoid stroma and branched vessels were observed,with hyaline degeneration around the vessel walls.The cells were spindle-shaped,fusiform,oval,or star-shaped.Immunophenotyping showed that ALK(D5F3)was positive expressed diffusely in the nucleus,CD34 was positive and S-100 was negative.FISH detected a positive break in the ALK gene.Next generation sequencing identified the ALK-EML4 fusion gene.Conclusion ALK-rearranged spindle cell tumor is a rare soft tissue tumors that have not yet been included in the WHO classification.This case requires differentiation from other soft tissue tumors with mucoid stroma,and immunohistochemistry and molecular testing are helpful for diagnosis.Due to the rarity of reports on this tumor,its exact long-term clinical biological behavior remains unclear.
Keywords：ALKSpindle cellSoft tissueClinical pathologyMolecular pathology
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 412-416 )