Relationship between the expression of RANK,KIF4A,LASP1 in breast cancer tissues and clinicopathological features and prognosis
ZHANG Chao
LI Yun
HAN Peng
CHEN Wei-liang
Abstract：Objective To investigate the relationship between the expression of receptor activator of nuclear factor-kappa B(RANK),kinesin family member 4A(KIF4A),LIM and SH3 protein 1(LASP1)in breast cancer tissues and clinicopathological features and prognosis.Methods A total of 127 patients with breast cancer admitted to our hospital from April 2021 to April 2022 were selected as the study subjects.Immunohistochemical staining was applied to detect the expression levels of RANK,KIF4A,and LASP1 proteins in cancerous tissue and paracancerous tissues.The patients with breast cancer were followed up for two years after surgery,and their survival was recorded.Kaplan-Meier survival curve was used to analyze the correlation between the survival of patients and the expression of RANK,KIF4A,LASP1 in breast cancer.COX regression was used to analyze the prognostic factors of the patients.Results The positive rates of RANK,KIF4A and LASP1 in breast cancer tissues were higher than those in adjacent tissues(P＜0.05).The expression of RANK,KIF4A and LASP1 in breast cancer was related to the degree of lymph node metastasis,tissue differentiation and TNM stage(P＜0.05).After two years follow-up of breast cancer patients,24 died and 103 survived among the 127 breast cancer patients,with a survival rate of 81.10%(103/127).Kaplan-Meier survival curve showed that the 2-year survival rates of patients with positive expression of RANK,KIF4A and LASP1 in breast cancer tissue were lower than those of patients with negative expression of RANK,KIF4A and LASP1(P＜0.05).COX regression analysis showed that lymph node metastasis and the positive expression of RANK,KIF4A,LASP1 in breast cancer tissues were the risk factors for prognostic death of breast cancer patients(P＜0.05).Conclusion The positive expression of RANK,KIF4A and LASP1 in breast cancer tissue is related to the clinicopathological characteristics and prognosis of patients.
Keywords：Breast cancerReceptor activator of nuclear factor-kappa BKinesin family member 4ALIM and SH3 protein 1Clinicopathological featuresPrognosis
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 407-411,421 )