Clinical and pathological analysis of 5 cases of Chronic Histiocytic Intervillositis
LI Xu-mei
JIAN Jie
ZHANG Yun-yun
ZHANG Qi
ZHUO Wen-yan
CHEN Yan-lin
Abstract：Objective This study aims to explore the pathogenesis,clinicopathological characteristics,immunophenotype,and differential diagnosis of Chronic Histiocytic Intervillositis(CHI).Methods Five cases of CHI diagnosed between January 2018 and February 2024 were collected from Chongqing Maternal and Child Health Hospital and Changshou District Maternal and Child Health Hospital.Organize clinical data,observe its morphological characteristics and immunophenotype,and review the literature.Results All five cases of CHI were patients who had a miscarriage,and B-ultrasound all suggested embryonic arrest.Under the microscope,there was a mononuclear cell infiltration in the intervillous space with different degrees of fibrinoid deposition around the villi,and immunohistochemical markers of monocytes such as CD68,CD38,CD163,CD11C,HLA-DR were positive,indicating the presence of complement activation and inflammatory response.Conclusion CHI is a rare lesion closely related to adverse pregnancy outcomes.Pathological morphology combined with relevant immunophenotype can help identify it.
Keywords：Chronic histiocytic intervillositisPathological featurePathogenesisImmunophenotypeDifferential diagnosis
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 402-406 )