Bilateral ovarian endometriotic cysts with Krukenberg tumor as the primary lesion of clear cell carcinoma:Clinical and pathological features
LIU Sha
YE Cheng-lin
ZHANG Xiu-yun
HE Hui-hua
XU Li
Abstract：Objective: To explore the clinical manifestations and pathological characteristics of double-sided ovarian endometrioid cysts combined with Krukenberg tumor, with clear cell carcinoma as the primary lesion. Methods: Clinical and pathological data of one case of double-sided ovarian endometrioid cysts combined with Krukenberg tumor diagnosed in the Department of Pathology of Wuhan University People's Hospital were collected, and immunohistochemistry and literature review were performed. Results: The patient was a 44-year-old female. Under the microscope, the bilateral ovarian cysts showed signet-ring cells and endometrial-like glands. A gray-white mass was found in the right adnexa. Under low magnification, the tumor cells were diffusely arranged in sheets. Under high magnification, the tumor cells appeared polygonal or boot-shaped, with abundant cytoplasm and large nuclear atypia. Many signet-ring cells were found in the lymph nodes removed during surgery. Immunohistochemistry showed that the signet-ring cells were positive for CK7, Villin, and CDX2, and negative for Pax8; the gray-white mass was positive for CK7, NapsinA, and Pax8, and negative for ER and WT-1. Gastric endoscopy biopsy showed scattered signet-ring cells in the gastric mucosa. Conclusion: Clear cell carcinoma as the primary lesion in double-sided ovarian endometrioid cysts combined with Krukenberg tumor is extremely rare. It is necessary to comprehensively analyze the patient's clinical history to avoid misdiagnosis.
Keywords：Clear cell carcinomaEndometrioid cystKrukenberg tumorClinical featuresPathological features
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 305-308 )