Lymphoepithelial-like carcinoma with adenoid differentiation of renal pelvis:a case report
YU Di-ping
LAN Song
PENG Juan
SHU Zhong-long
Abstract：Lymphoepithelioid-like carcinoma (LELC) is a malignant epithelial tumor characterized by a rich lymphocytic stroma. LELC occurring in the renal pelvis is rare, and differs from LELC in the nasopharynx, lung, etc., as it is not directly associated with Epstein-Barr virus (EBV). It lacks specific clinical manifestations, making preoperative diagnosis difficult. The definitive diagnosis relies on histopathology and immunohistochemistry. Histologically, the tumor cells show a nested, cord-like, or single-cell pattern, with local glandular structures. The stroma is rich in lymphocytes. Immunohistochemically, the tumor expresses urothelial markers such as GATA-3 and Uroplakin III, and EBER in situ hybridization is negative. We report a case of LELC in the renal pelvis, discuss its clinicopathological features, immunophenotype, and differential diagnosis to enhance awareness of this lesion among clinicians and pathologists.
Keywords：Lymphoepithelioid-like carcinomaRenal pelvisGlandular differentiationClinical pathological featuresDifferential diagnosis
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 231-232,后插1 )