Mesonephric-like adenocarcinoma in uterus:a clinicopathological study of three cases
ZHANG Wei-xuan
LI Zhi-wei
ZHANG Wei
Abstract：Objective To investigate the clinicopathological features,immunophenotype and molecular genetic changes of mesonephric-like adenocarcinoma(MLA).Methods The clinical data of 3 MLA patients were collected and detected by HE stain,immunohistochemical EnVision staining and PCR.The clinicopathological features were analyzed and related literature was reviewed.Results The average age of the three patients was 63 years.All of them presented with irregular vaginal bleeding.The maximum diameter of the tumor was about 1.0～5.1 cm,and the section was gray and solid.Microscopically,the tumor cells showed a papillary,glandular,solid lamellar arrangements.Some lumen contained light red serous fluid;the cell size was consistent,with less cytoplasm,eosinophilic,partially transparent cytoplasm,round or oval nuclei,deeply stained chromatin,irregular nuclear membrane,and visible nuclear furrows.Hyaline degeneration of vascular walls in some interstitial regions was noted.Immunophenotypically,PAX2,PAX8,GATA3,TTF-1,CD 10,vimentin,MLH1,MSH2,MSH6,PMS2,and CK7 were all positive,among which CD 10 was positive for the lumen and endometrial stromal deletion,GATA3,TTF-1,p16,and CK7 were partially positive.ER,PR,WT1 were negative,p53 was wild type,and Ki-67 index was about 70％.KRAS gene mutation was detected in 2 cases and PIK3CA gene mutation in 1 case.Conclusion MLA is a rare gynecological malignant tumor with unique histological,immunophenotypic and molecular genetic features.It is more invasive and has a poor prognosis.
Keywords：Mesonephric-like adenocarcinomaClinicalPathologyImmunohistochemistryMolecular genetics
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 171-174,181 )