Hydatid mole misdiagnosed as cervical malignancy by Thinprep cytologic test:report of a case
ZHOU Bao-kun
LIU Xiao-li
XU Ting
ZHANG Xiao-fang
LIU Hong-li
ZHANG Teng
ZHAO Lin-li
WANG Jian-li
Abstract：Objective To explore the cytological features of cervical liquid-based cytology (TCT) in patients with hydatidiform mole (also known as molar pregnancy), and to provide assistance for clinical diagnosis. Methods A case of hydatidiform mole misdiagnosed as malignant tumor by cervical liquid-based cytology (TCT) was collected and analyzed. Results The patient denied a history of sexual intercourse, physical examination showed no obvious positive signs, and ultrasound did not suggest hydatidiform mole. Additionally, the β-hCG test results were unknown. TCT revealed a large number of dispersed, large mononuclear cells with increased nuclear-cytoplasmic ratio and deeply stained nuclei. Histopathology showed edema of the villous stroma and proliferation of trophoblastic cells, and immunohistochemistry indicated p57 negativity, leading to a diagnosis of complete hydatidiform mole. Conclusion During cervical cell diagnosis, when multinucleated giant cells or trophoblastic (and/or intermediate trophoblastic) cells are found, even without clinical history or auxiliary examinations, the possibility of hydatidiform mole should be considered to avoid misdiagnosis.
Keywords：Cervical liquid-based cytologyHydatidiform moleMolar pregnancyCervical squamous cell carcinomaTrophoblastic cell
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 106-107,113 )