Cutaneous Rosai-Dorfman disease:report of two cases
CHENG Shu-ya
BAI Yu-ping
WANG Qiao-yun
LIU Fu-jin
Abstract：Objective To investigate the clinical and pathological features of cutaneous Rosai-Dorfman disease (CRDD). Methods Analyzed the clinical, pathological, and immunophenotypic characteristics of two cases of CRDD, and reviewed the literature. Results Both patients were young women, with clinical manifestations including a pale red patch on the left temporal region with pruritus or a mass in the right lower abdominal wall. No lymph node enlargement or organ involvement was found through related auxiliary examinations and physical and hematological examinations. Histopathological examination of skin lesions showed nodular infiltration of histiocytes in the dermis and subcutaneous tissue, accompanied by infiltration of lymphocytes and plasma cells, presenting as alternating light and dark bands. The cells had abundant cytoplasm and were eosinophilic, with the presence of "infiltration phenomenon." Immunohistochemistry: In both cases, the histiocytes were positive for CD68 and S-100, and negative for CD1a and ALK. Conclusion CRDD is a rare non-Langerhans cell histiocytic disorder, limited to the skin without involvement of lymph nodes or other parts of the body. Its clinical presentation is not specific, leading to frequent missed or misdiagnosis. The diagnosis mainly relies on histopathology and immunohistochemistry.
Keywords：Cutaneous Rosai-Dorfman diseaseNon-Langerhans cell histiocytosisHistiocytic tumorClinical featuresImmunohistochemistry
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 103-105 )