Primary myxoid liposarcoma of the uterus:report of a case and review of literature
CHEN Jia-xing
ZHANG Rong-jun
LI Zhai-feng
ZHUANG Shan-ni
Abstract：Objective To explore the clinical symptoms, pathological features, and molecular genetic characteristics of primary uterine myxoid liposarcoma (UMLPS). Methods A case of UMLPS was analyzed by clinical pathology, immunohistochemistry, and FISH testing, and relevant literature was reviewed. Results The patient was a 65-year-old female presenting with lower abdominal discomfort. MRI showed a large mass in the myometrium at the bottom of the uterus. Histologically, the tumor showed a myxoid background with branching capillaries, and the tumor cells were adipoblasts at different stages of maturation. Immunophenotype showed expression of p16, NY-ESO-1, S-100, STAT6, CD34, and Rb, with partial expression of CDK4 and MDM2, but no expression of DDIT3, Desmin, SMA, or CD10. FISH testing revealed positive DDIT3 gene rearrangement. Postoperative follow-up for 5 months showed no disease. Conclusion UMLPS is a rare uterine soft tissue tumor. Surgery is the main treatment, and adjuvant radiotherapy and chemotherapy may be used in some cases. The prognosis is uncertain and more primary cases are needed for clinical prognosis evaluation.
Keywords：UterusMyxoid LiposarcomaDDIT3NY-ESO-1Diagnosis
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 70-73 )