Clinicopathological featuers of primary SMARCA4-deficient gallbladder carcinoma
FAN Rui-rui
Abstract：Objective To analyze the clinical and pathological characteristics of primary SMARCA4-deficient cholangiocarcinoma. Methods Clinical data of one patient with primary SMARCA4-deficient cholangiocarcinoma were collected, and the clinical and pathological features were analyzed by HE staining and immunohistochemistry. Results Under the microscope, the tumor cells were arranged in a diffuse sheet-like pattern, mainly spindle-shaped and oval cells, some showing epithelioid morphology, some sarcomatoid, with a few cells losing adhesion, nuclei located at the periphery with rhabdoid appearance, obvious nuclear atypia, frequent pathological mitotic figures, and a small amount of adenocarcinoma mixed in. Immunohistochemistry: Tumor cells expressed CK, CK7, EMA, CAM5.2, and INI-1, but did not express Brg-1, MyoD1, S100, Desmin, or CD34. Conclusion Primary SMARCA4-deficient cholangiocarcinoma is rare, with diverse pathological morphology and poor prognosis, and is easily misdiagnosed. Timely and accurate diagnosis has important guiding significance for the treatment and prognosis of patients.
Keywords：CholangiocarcinomaSMARCA4Malignant TumorHistopathologyDiagnosis and Differential Diagnosis
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 54-56 )