Clinicopathological features of ovarian sclerosing stromal tumor
WANG Hong-qun
LI Jin-hang
LI Xiao-yue
MA Ya-qi
CHEN Wei
GAO Han-xiao
ZHU Ya-nan
SONG Xin
LIU Ai-jun
Abstract：Objective Ovarian sclerosing stromal tumor(SST)is a rare neoplasm.This study aims to investigate the clinicopathological features of SSTs.Methods The clinicopathological data of 25 patients were collected and analyzed,and PCR-capillary electrophoresis was used to detect the gene status of FOXL2 and DICER1 in 10 cases.Results The patients were aged 11-58 years,with a median age of 25 years.There were 13 cases(52.0％)of SSTs occurring on the left side,12 cases(48.0％)on the right side.Some patients(80.0％)had shortened menstrual cycle,some accompanied with abdominal pain.Ultrasound showed mixed low echo in most patients,solid area was low echo,CDF1 showed that solid area,the periphery of the mass and cystic area showed rich blood flow signal.The majority of patients(76.2％)presented varying degrees of abdominopelvic cavity effusion.Gross were mostly cystic and solid mass(78.9％).The section was gray or grayish yellow or red color.Histologic findings were that the tumors were lobulated,with alternating pattern of hypercellular and hypocellular areas,solid area was usually located in the periphery of the mass,with rich blood sinus accompanying fissured and dilated.The abundant blood sinuses were surrounded by tumor cells,and cell border was not clear.The cytoplasm was reddish to pale in some cells.The nuclei were ovoid or fusiform.Nuclear chromatin was fine with vesicular nuclei.The small nucleoli were seen in some cells.Scattered collagen was distributed between cells.In a small part of cases,signet ring cell was seen.A small spider-like cells may be present.Loose area showed edema with sparse cells.Some cases had blood sinus with fibrinoid exudation;others had loose fibres or collagen.Immunohistochemistry showed that Vimentin was positive.Partial tumor cells showed SMA positive expression.Inhibin-α,Calretinin,and CD99 had varying degrees of positive staining.In most cases,PR was widely staining,while EMA and S-100 were negative.Most of the Ki-67 index were less than 10.0％.PCR-capillary electrophoresis showed no mutations in FOXL2 and DICER1(0/10).Follow-up data showed all patients were uneventful after surgery.Conclusion Patients with SST have a good prognosis after tumor resection.Preoperatively they may be misdiagnosed.There are no mutations FOXL2 and DICER1 genes in the SST.
Keywords：Ovarian sclerosing stromal tumorHistopathologyImmunohistochemistryGenetic testingPrognosis
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 43-48,82 )