Encapsulated papillary carcinoma of the breast:A clinical and pathological analysis of 12 cases
LEI Jian-yuan
CHEN Lin
LI Wen-sheng
LIU Jie
WANG Ping
Abstract：Objective To investigate the clinicopathological features,diagnosis,differential diagnosis,and prognosis of encapsulated papillary carcinoma(EPC)of the breast.Methods Retrospective analysis of the clinical data of 12 cases of EPC was conducted to summarize its pathological features,immune phenotype,and prognosis,and review relevant literature.Results There were 11 female and 1 male,aged 34-84 years(median 64 years).Diameter of tumors was from 1 cm to 6.8 cm(median 3.2 cm).Microscopically,the tumor cells within the fibrous capsule were arranged in papillary and cribriform patterns,with low to moderate nuclear atypia,and 2 cases showed apocrine differentiation.Immunohistochemistry showed positivity for ER(10/12),PR(10/12),AR(5/8),and GCDFP15(1/1),while the capsule wall and intramural myoepithelial markers were negative.There were 2 cases of pure EPC,4 cases of EPC with ductal carcinoma in situ(DCIS),and 6 cases of EPC with invasion.No recurrence or metastasis was observed during the follow-up period.Conclusion EPC predominantly occurs in elderly women,with indolent biological behavior,often accompanied by DCIS or invasion.Apocrine EPC is rare.Accurate diagnosis requires comprehensive judgment based on adequate sampling,morphological characteristics,and immunohistochemistry.
Keywords：Encapsulated papillary carcinomaApocrine typeBreastPathology
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 23-26,99 )