Application of FNAC combined with multi-gene detection in diagnosis of thyroid nodules
WANG Ruo-xi
FU Zhen-peng
XIE Xiao-ping
QU Mei-ting
DONG Wei
Abstract：Objective To explore the application value of FNAC(fine needle aspiration cytology)combined with multi-gene testing in the diagnosis of thyroid nodules.Methods A tatal of 204 patients with thyroid nodules who met the inclusion criteria were selected.All patients underwent preoperative FNAC examination and multi-gene testing(7 gene loci including BRAF,KRAS,HRAS,NRAS,TERT,NTRK,RET/PTC).Postoperative pathological sections were used as the"gold standard"to analyze the value of FNAC combined with multi-gene testing in the diagnosis of thyroid nodules.The postoperative pathology showed that the combination of FNAC and multi-gene detection had a strong consistency with the pathological findings.Results Compared with FNAC and multi-gene mutation detection alone,the sensitivity of the combined diagnosis was higher,at 97.54％with a Kappa value of 0.907,and the difference was statistically significant(P＜0.01).The accuracy of the combined detection was 95.59％,which was higher than that of FNAC and multi-gene mutation detection alone,and the difference was statistically significant(P＞0.05).Conclusion Therefore,the combination of FNAC and multi-gene testing can significantly improve the accuracy and sensitivity of thyroid nodule diagnosis.
Keywords：Thyroid nodulesThyroid tumorFNACBRAF geneMulti-gene testing
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 8-12 )