Clinicopathological features of the gastric adenocarcinoma withenteroblastic differentiation
FAN Rui-rui
WANG Gui-mei
Abstract：Objective To investigate the clinicopathological features of the gastric adenocarcinoma with enteroblastic differentiation(GAED).Methods Clinicopathological data of GAED were collected and analyzed by H&E staining,immunohistochemistry,and FISH.Results Both patients were male.One patient had superficial protuberant type and the other had ulcerative type.Microscopically,the tumor cells were arranged in glandular,cribriform structures,cuboidal or columnar,with relatively clear cell borders and abundant clear cytoplasm.Vascular invasion was present in both cases.Immunohistochemical staining results showed tumor cells were positive for CDX2(2/2),CD10(2/2),SALL4(2/2),Heppar-1(2/2),Glypican-3(2/2),AFP(2/2),HER2(1/2,3+).FISH showed HER2 gene amplification(1/2).Conclusion Gastric adenocarcinoma with enteroblastic differentiation is a rare disease with relatively characteristic histomorphology and immunophenotype.The prognosis is worse than that of common adenocarcinoma.
Keywords：StomachAdenocarcinomaEnteroblastic differentiationHistopathologyDiagnosis and differential diagnosis
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1064-1067 )