Expression of lncRNA ITGA9-AS1 and miR-670-3p in hepatocellular carcinoma tissues and their relationship with prognosis of patients
FANG Li
ZHAO Xiang-rong
GUO Xiao-juan
WU Shi-qian
Abstract：Objective To explore the expression and prognosis evaluation value of long non-coding RNA(lncRNA ITGA9-AS1)and miR-670-3p in hepatocellular carcinoma(HCC)tissue.Methods Seventy-six patients with HCC who were admitted to our hospital from June 2016 to June 2018 were selected as the research objects,and their cancer tissues and corresponding paracancerous tissues were taken as the HCC group and the precancerous group,respectively.The levels of lncRNA ITGA9-AS1 and miR-670-3p were detected by real-time quantitative PCR(qRT-PCR);Pearson correlation was used to analyze the relationship between lncRNA ITGA9-AS1 and miR-670-3p;Kaplan-Meier method for analyzing survival curves;COX regression analysis of influencing factors.Results In HCC group,lncRNA ITGA9-AS1 level was low,and miR-670-3p level was high(P＜0.05).lncRAN ITGA9-AS1 was negatively correlated with miR-670-3p(r=-0.310,P=0.006).The expression levels of lncRNA ITGA9-AS1 and miR-670-3p were correlated with TNM stage,lymph node metastasis,tumor differentiation,tumor size,and tumor number(P＜0.05).After 3 years of follow-up,the cumulative survival rate of lncRNA ITGA9-AS1 patients in the high expression group was higher than that in the low expression group.The cumulative survival rate of patients with high expression of miR-670-3p was lower than that of patients with low expression(P＜0.05).Multivariate COX regression analysis showed that tumor differentiation(HR=1.842),lymph node metastasis(HR=3.882),miR-670-3p(HR=3.786)and lncRNA ITGA9-AS1(HR=3.366)were the factors affecting the prognosis of HCC patients(P＜0.05).Conclusion The lncRNA ITGA9-AS1 is lowly expressed and miR-670-3p is highly expressed in HCC tissue.The levels of the two are closely related to clinicopathological characteristics and have a certain value in evaluating the prognosis of HCC patients.
Keywords：HCClncRNA ITGA9-AS1miR-670-3pprognosis
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1055-1059 )