Primary pigmented nodular adrenocortical disease:a clinicopathological analysis and review of literature
ZHOU Hao-tan
CHEN Dong
YU Wei
Abstract：Objective To investigate the clinicopathological characteristics of primary pigmented nodular adrenocortical disease(PPNAD).Methods Clinical data,imaging studies,and pathological features were collected from two PPNAD patients treated at Beijing Anzhen Hospital of Capital Medical University,from January 2009 to June 2023.Hematoxylin and eosin(HE)staining and immunohistochemical staining were performed to analyze the histomorphological and immunohistochemical characteristics.Relevant literature was reviewed.Results The first case involved a 31-year-old male with a tumor in the right adrenal gland.The second case involved a 63-year-old female with a tumor in the left adrenal gland.Microscopically,the adrenal cortex exhibited multinodular hyperplasia.The hyperplastic nodules were primarily composed of large granular eosinophilic cells containing varying amounts of lipofuscin in their cytoplasm.Immunophenotypically,the cells expressed Syn,CD56,α-Inhibin,and SDHB positively,while NSE and CK showed partially positive expression.CgA,S-100,and EMA were negatively expressed,with a Ki-67 proliferation index of approximately 2%.The pathological diagnosis was primary pigmented nodular adrenocortical disease.Conclusion PPNAD is rare and requires a comprehensive diagnosis combining imaging,histopathology,and immunohistochemical staining.Genetic testing may be necessary to confirm the diagnosis.
Keywords：Adrenal glandPrimary pigmented nodular adrenocortical diseaseClinicopathologic featureGene detection
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1046-1049 )