Clinicopathological features of renal oncocytoma
HUO Yuan-yuan
LI Gen
HAO Xiang-yun
ZHANG Yu
ZHANG Tao-tao
Abstract：Objective To introduce the clinical features of renal oncocytoma,and to explore the clinicopathological features,immunohistochemical phenotype,diagnosis,differential diagnosis and prognosis of renal oncocytoma.Methods The clinical data,histological features and immunohistochemical phenotype of 7 cases of renal oncocytoma were retrospectively analyzed with the review of relative literature.Results Histologically,the tumor tissue was well circumscribed.The tumor cells were arranged in solid nests and tubes.The stroma was loose,edematous and mucous with sparse cells.Immunohistochemically,AE1/AE3 was positive(7/7),CD117 positive(7/7),Pax8 positive(7/7),S100A1 positive(6/7),Cathepsin K positive(5/7),P504s positive(1/7),CK7 partially positive(2/7),Vimentin positive(0/7),CD82 positive(0/7),Claudin7 positive(0/7),CD10 positive(0/7),and Ki-67 index(1%-4%).Conclusion RO is a rare benign renal epithelial tumor.The diagnosis needs to be considered in combination with histology and immunohistochemistry.The expression of CD117,Pax8,S100A1,Cathepsin K,CK7,Claudin7 and CD82 in tumor cells is of vital importance to its diagnosis.The nephron-sparing surgery is recommended.They have a relatively good prognosis.Therefore,correct diagnosis is of great significance for clinical treatment.
Keywords：Renal tumorOncocytomaImmunohistochemistryDifferential diagnosis
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1042-1045 )