Clinicopathological features of primary rectal goblet cell adenocarcinoma
FAN Rui-rui
GAO Jie
Abstract：Objective To investigate theclinicopathological features ofthe primary rectal goblet cell adenocarcinoma(GCA).Methods Clinicopathological data of primary rectal GCA were collected and analyzed by H&E staining,immunohistochemistry,special staining,transmission electron microscopy and next generation sequencing(NGS).Results GCA was composed of goblet-like cells with rich mucus in the cytoplasm,neuroendocrine cells,and Paneth-like cells.The tumor cells arranged as nest-like distribution.Immunohistochemical staining results showed tumor cells were positive for CK,CK20,CDX2,SSTR2,Syn.D-AB/PAS staining result showed there was some mucus in tumor cells.TEM result showed the neuroendocrine granules and mucous vesicles were observed in the same goblet-like cell of the tumor tissue.NGS results showed ERBB2 and P53 missense mutations in the tumor.Conclusion Rectal GCA is relatively rare.This study has in-depth analysis of clinical and pathological features of primary rectal GCA at electron microscopic and molecular levels,which provides basis for clinical accurate treatment.
Keywords：RectumGoblet cell adenocarcinomaHistopathologyDiagnostic basisDifferential diagnosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 976-979,988 )