Clinicopathological features of metastatic endocrine mucin-producing sweat gland carcinoma in lung
YANG Wen-sheng
SHEN Yan-ling
LIU Xue-qing
Abstract：Objective To investigate the clinicopathological features,diagnosis and differential diagnosis of endocrine mucin-producing sweat gland carcinoma(EMPSGC).Methods The clinicopathological features and immunophenotype of a patient with lung metastatic EMPSGC were analyzed retrospectively,and the related literature was reviewed.Results The patient was a 53-year-old male with a history of left axillary sweat gland adenoid cystic carcinoma for 10 years.Three months ago,the patient began to present symptoms of cough and sputum without obvious causes.The histopathology of the bronchoscopic biopsy specimen showed that tumor tissue was found below the normal bronchial mucosa,and the tumor cells were solid and sieve shaped,with no obvious atypia.A small amount of mucous was found inside and outside the tumor cells.There was no necrosis.Immunohistochemistry showed strongly diffuse positive for CK(P),EMA,GATA3,AR,ER,PR,Mucin-2,moderately positive for INSM1,partial positive for mammaglobin and GCDFP-15.CK7,CK20,TTF-1,NapsinA,P63,Syn,CgA,S-100,CD117,Dog1 and Pan-TRK were negative,and the proliferation index of Ki-67 was about 10%.Conclusion EMPSGC is a rare low-grade malignant sweat gland tumor expressing neuroendocrine markers.It may recur locally,and distant metastasis in rare cases.At present,more case studies are needed to investigate the risk factors for recurrence and the incidence of distant metastasis.
Keywords：Skin tumorEndocrine mucin-producing sweat gland carcinomaNeuroendocrine markerClinical pathologyImmunohistochemistry
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 948-951,956 )