Angiomyomatous hamartoma of lymph node:a clinicopathological analysis of five cases

XIAO Min; GE Xiao-xia; QU Li-juan; WANG Ming-yue

doi:10.3969/j.issn.1007-8096.2024.04.008

Abstract：Objective To Explore the clinical-pathological characteristics,pathogenesis,diagnosis,and differential diagnosis of angiomyomatous hamartoma of lymph node(AHL).Methods Retrospective analysis of the clinical data of 5 cases of AHL in the Department of Pathology of 900th Hospital of the Joint Logistics Support Force was conducted to summarize its pathological features,immune phenotype,and prognosis,and review relevant literature to explore its possible pathogenesis.Results Among the 5 cases of AHL,there were 3 males and 2 females,age ranged 21-77 years,median 55 years.Grossly,the section of the lesion was a gray white and tough texture.Microscopically,the lymph node parenchyma was replaced by irregularly proliferating thick walled blood vessels,smooth muscle cells,and fibrous tissue,the lesion extended from the hilum to the parenchyma,and the proliferating smooth muscle cells surrounded the blood vessel wall or irregularly penetrated the fibrous tissue.Immunophenotypically,the IHC of SMA and Desmin were both(+)in smooth muscle tissue;Pathological diagnosis was angiomyomatous hamartoma of lymph node.Conclusion Lymph node angiomyomatous hamartoma is rare in clinical practice,and some pathologists have insufficient understanding of this disease.They need to improve their understanding of this disease and to avoid misdiagnosis and missed diagnosis.