Expression and prognostic relationship of GATA binding protein 3 and sex determination-related gene cluster 2 in triple-negative breast cancer
LIN Jia-nan
WANG Li-zhong
YU Yin-ping
JIANG Wei-hua
Abstract：Objective To investigate the expression and prognostic relationship of GATA binding protein 3(GATA3)and sex determination related gene cluster 2(SOX2)in triple-negative breast cancer(triple-negative breast cancer,TNBC).Methods A total of 140 cases of TNBC and adjacent cancer tissue were collected,and the expression levels of GATA3 and SOX2 in TNBC were detected by immunohistochemical staining,and the characteristics of GATA3 and SOX2 expression,clinicopathological characteristics and prognosis in TNBC were analyzed.Results The expression rate of GATA3 in TNBC and adjacent tissues(82.86％,98.00％),and the expression rate of SOX2 in TNBC and adjacent tissues were(56.43％and 5.00％,respectively),which were statistically significant(P＜0.05).Positive GATA3 expression was associated with low histological grade and lymph node metastasis in TNBC patients(P＜0.05),and positive SOX2 expression showed low histological grade and Ki-67 proliferative expression in TNBC patients(P＜0.05).The 5-year disease-free survival rate of patients with GATA3 positive expression and SOX2 positive expression was 78.35％(91/116)and 62.02％(49/79),respectively,which were statistically significant(P＜0.05).Conclusion GATA3 positive rate in TNBC is significantly lower than in adjacent tissues,and SOX2 positive rate is higher than adjacent tissues.GATA3 deficiency expression and SOX2 overexpression are immunohistochemical indicators of poor prognosis of breast cancer patients,and are expected to be an important basis for prognosis evaluation of breast cancer patients.
Keywords：Triple-negative breast cancerGATA-3SOX2Prognosis
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 140-144 )