Expression of HNF-1β in pancreatic ductal adenocarcinoma and its diagnostic value
WEI Xue
ZHANG Ru-song
CAO Yang
CHENG Kai
WANG Xuan
MA Heng-hui
RAO Qiu
FANG Ru
Abstract：Objective To investigate the expression of Hepatocyte nuclear factor 1β(HNF-1β)in pancreatic ductal adenocarcinoma(PDAC)and its diagnostic value.Methods 49 cases of PDAC were collected from January 2021 to January 2023,and the expressions of HNF-1β,CK7,CK20,PAX-8,GATA-3,NapsinA,TTF1,ER,PR,NKX3.1 and RCC were detected by immunohistochemical EnVision method.The positive rates of various tumor markers were compared.Results The positive rate of HNF-1β was 85.7％(42/49),of which 45.2％(19/42)cases were strongly positive,14.3％(6/42)cases were moderately positive,and 40.5％(17/42)cases were weakly positive.The positive rate of CK7 was 83.7％(41/49).The positive rate of CK20 was 4.1％(2/49).PAX-8,GATA-3,Napsin A,TTF1,ER,PR,NKX3.1 and RCC were all negative,and the positive rate was 0％(0/49).Conclusion HNF-1β combined with other lineage-specific tumor markers may be helpful in the diagnosis of PDAC and differential diagnosis from adenocarcinoma of other origin.
Keywords：Pancreatic ductal adenocarcinomaHNF-1βTissue microarrayImmunohistochemistry
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 12-15 )