Relationship between ATM gene polymorphism and immunohistochemical expression in breast cancer
PAN Si-qiong
LU Feng-ke
QIAO Shu-ye
CHEN Miao-yu
YI Min
Abstract：Objective To investigate the correlation between rs4585 single nucleotide polymorphism(SNP)and immunohistchemical expression of Ataxia-Telangiectasia mutated gene(ATM)in the pathogenesis and development of breast cancer.Methods Multiple SNaPshot method was used to study the polymorphism of ATM gene rs4585 locus,including 56 cases of breast cancer and 72 cases of benign breast tumor.Estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)and Ki-67 proteins were detected in breast cancer tissues.To analyze the relationship between genotype and breast cancer.Results There was no correlation between ATM gene rs4585 genotype distribution and breast cancer(P>0.05).There was no correlation between theexpression of ER,PR,HER2,Ki-67 and breast cancer(P>0.05).Conclusion ATM gene rs4585 polymorphism may not be associated with genetic susceptibility,clinicopathological features and immunohistochemical indexes of breast cancer.
Keywords：Breast cancerAtaxia-telangiectasia mutated genePolymorphismImmunohistochemical
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1098-1101 )