Correlation between expression of P53 and EGFR in oral squamous cell carcinoma and clinicopathology and prognosis

LI Zhi-rui; LI Xiao-yue; LIU Ai-jun; CHU Bing-feng; LIN Yan-die

doi:10.3969/j.issn.1007-8096.2023.10.013

Abstract：Objective This study aimed to evaluate the expression of p53 and EGFR in oral squamous cell carcinoma(OSCC)and explore their relationship with tissue differentiation,T and N stage,clinical stage,and prognosis.Methods A retrospective analysis was conducted on 102 OSCC patients who underwent surgical treatment.Immunohistochemical staining was performed to determine the expression levels of EGFR and p53 in tumor tissues.Clinical and pathological data were collected and analyzed using SPSS 21.0.Results In OSCC patients,the degree of tumor differentiation was correlated with clinical stage and lymph node metastasis(Pearson R=0.38,P<0.001;Pearson R=0.25,P=0.008).The positive expression rate of p53 in OSCC was 63.7%,and p53(mutation)expression was correlated with tumor differentiation(Pearson R = 0.3,P = 0.002).The positive expression rate of EGFR in OSCC was 70.6%,and its expression increased with tumor size and infiltration,with significant differences(P = 0.02).Kaplan-Meier analysis showed that OSCC patients with p53(mutation)had a significantly lower 3-year progression-free survival(PFS)compared to those with p53(null)and p53(wild type),with statistical significance(P=0.04).However,there was no significant difference in 3-year PFS between EGFR(-)and EGFR(+)OSCC patients.Conclusion p53 and EGFR proteins were highly expressed in oral squamous cell carcinoma tissues.p53(mutation)was associated with tumor differentiation and indicated a poorer prognosis.EGFR expression was correlated with tumor T stage.These findings suggest that p53 and EGFR may be potential important factors in the occurrence and development of OSCC.