Colorectal cancer with ovarian metastasis:a clinicopathologic study of 14 cases
XIE Jian-jun
ZHANG Yong-huan
DU Ran
SHI Xiao-lan
LIU Fang
LI Bo
Abstract：Objective To explore the clinicopathological characteristics of ovarian metastatic tumors of colorectal cancer(CRC).Methods Fourteen cases of CRC ovarian metastasis were collected,and their clinical features,pathology and immunohistochemistry were analyzed.Results The patients were aged 47-79 years,with a median age of 59 years.Nine cases had omental/peritoneal nodules or ascites,eight cases had unilateral ovarian metastasis,and three cases had bilateral lesions with asymmetric enlargement,with tumor diameters ranging from 2.5 to 23.0 cm.Microscopically,most cases showed expansive infiltration,with morphological changes similar to primary ovarian mucinous tumors.A few cases showed mucinous adenocarcinoma or signet ring cell morphology,and epithelial-mesenchymal clefts were easily seen.Immunophenotypeically,tumor cells were positive for CK20,SATB2,CDX2,and negative or weakly positive for CK7.Three cases were misdiagnosed as primary ovarian tumors by intraoperative frozen section.Conclusion CRC ovarian metastasis is more common in unilateral ovaries,and in bilateral ovarian metastasis,the bilateral lesions may show asymmetric enlargement.The diagnosis should be based on the history,intraoperative findings,histological features and immunohistochemistry.The diagnosis of CRC ovarian metastatic tumors needs to focus on the differentiation from primary ovarian mucinous tumors.
Keywords：Colorectal carcinomaOvarian metastasisPrimary ovarian mucinous tumorHistological featureImmunohistochemistry
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 969-972 )