Pulmonary Langerhans cell histiocytosis:a clinicopathologic analysis
HUANG Qiao-na
WU Yong-he
WANG Yi-jun
ZOU Zong-kai
CHEN Shun-ping
Abstract：Objective To investigate the clinical characteristics,imaging findings and pathological features of pulmonary Langerhans cell histiocytosis(PLCH),so as to improve the understanding and diagnosis rate of PLCH.Methods The clinical and imaging data,pathological features and prognosis of 7 PLCH patients were retrospectively analyzed.Results Among the 7 patients with PLCH,6 were male and 1 was female.The median age was 39 years,and 6 of them had smoking history.There were 3 cases of single-system PLCH and 4 cases of multi-system PLCH.CT showed single or multiple nodules and/or cystic shadows in the lungs.Histopathological features included diffuse proliferation of Langerhans cells to form granuloma-like nodules,interstitial infiltration of eosinophils with varying numbers.Immunohistochemical staining showed that Langerin,S-100,CD1a,Cyclin D1 were positive in the tumor cells.Conclusion PLCH is a rare lung disease,Immunohistochemistry is essential for accurate diagnosis.The imaging features of PLCH are of great value in diagnosis and staging,and closely related to pathological changes.The treatment of PLCH should be individualized according to the organ involvement.Smoking cessation,hormone therapy and/or systemic chemotherapy are important treatment method for PLCH involving multiple organs.
Keywords：Langerhans cellImmunohistochemistryCyclin D1BRAF V600E
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 965-968,986 )