Clinicopathological features of adrenocortical oncocytic neoplasms
YAN Guang-ning
LI Jing
YU Ling
YE Dan-li
ZENG Wei-peng
ZONG Jia-wen
WANG Zhuo-cai
Abstract：Objective To investigate the clinic-pathological features and the diagnostic criteria of malignant adrenocortical oncocytic neoplasms(ACONs).Methods Tumor samples of ACONs between 2007 to 2021 from our hospital were collected,and the clinical and pathological data were analyzed.Immunohistochemistry and reticular fiber staining were conducted on these samples.Results Patients with ACONs were vague clinical presentation.Tumors were solitary with intact capsule.Tumor cells were arranged in acinar or solid patches,with abundant capillary networks in the stroma.These cells were similarly enlarged in volume,polygonal and epithelioid shaped,rich in acidophilic cytoplasm.The nuclei were round with small and syllable nucleoli.Some tumor cells were apparently atypia.ACONs cells were positive for Syn,Melan-A,α-Inhibin,negative for CgA.Ki-67 index were 1%-30%.Using Lin-Weiss-Bisceglia score system,5 were malignant,6 were undetermined malignant potential,and 6 were benign.As to Helsinki score,13 were benign,1 was borderline,and 3 were malignant.Besides,13 of them were scored as no or few absence,while 4 of them were obviously absence,under reticular fiber scores system.Conclusion ACONs are rare,which malignant diagnostic criteria are still controversial.Prognosis prediction may rely on comprehensive assessment of these score systems and reticular fiber staining.
Keywords：Adrenocortical neoplasmsOncocyticLin-Weiss-BiscegliaHelsinkiReticular fibers
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 948-951,964 )