Secretory meningioma:clinicopathological analysis and literature review
MA Jin
SHEN Yao-yuan
LIU Lin-hua
SHAO Ming-yu
Abstract：Objective To investigate the clinicopathological features of secretory meningioma(SM).Methods The clinical and pathological features were observed and related literatures were reviewed.Results In the study,the majority of SM patients were women(7/11),with the lesions most commonly occurring on the convex surface of the brain(45.5％).Under the microscope,the characteristic eosinophilic secretions were found in all the cases,PAS staining was positive.The tumor cells were positive for Vimentin,CEA,PR,AE1/AE3(6/6),SSTR 2(4/4);EMA(10/11),S-100(1/10),the expression rate of Ki-67 value-added index was＜1％-4％.All the 11 cases were diagnosed as SM,WHO grade 1.6 had KLF4(K409Q)mutation,and I had TRAF7(G536S)mutation.9 patients were followed up for 5-55 months,and no recurrence or metastasis was found.Conclusion SM presents with unique pathological morphological features,and has a good prognosis.
Keywords：MeningiomaSecretory typeEosinophilic secretion
Publication Date：2023-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 880-883 )