Clinicopathological features of papillary thyroid carcinoma combined with primary Langerhans cell histiocytosis of the thyroid
JIA Hui
ZHAO Han
GUO Zhi-han
GU Hai-yan
LI Yu-jun
LIN Dong-liang
KAN Yan-ni
Abstract：Objective To investigate the clinicopathological features,immunophenotype,diagnosis and differential diagnosis of papillary thyroid carcinoma combined with primary Langerhans cell histiocytosis of the thyroid.Methods Two cases of papillary thyroid carcinoma with primary thyroid Langerhans cell histiocytosis were collected from the Affiliated Hospital of Qingdao University.HE and immunohistochemical staining were performed,and the BRAF gene status of the two components was tested via Sanger sequencing,respectively.Results Classic papillary thyroid carcinoma and Langerhans cell histiocytosis components were present in both cases.Hashimoto thyroiditis was found in one case.BRAF V600E mutation was detected in the papillary thyroid carcinoma component in both cases via Sanger sequencing,but no BRAF V600E mutation was found in the Langerhans cell histiocytosis component.Conclusion Papillary thyroid carcinoma combined with primary Langerhans cell histiocytosis is rare in the thyroid,and it may be misdiagnosed.Immunohistochemistry is helpful for the diagnosis.
Keywords：Thyroid papillary carcinomaLangerhans cell histiocytosisBRAF V600EHashimoto's thyroiditis
Publication Date：2023-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 876-879 )