Clinicopathologic characteristics and prognosis of undifferentiated thyroid carcinomas
WANG Hong-qun
LI Jie
LIU Peng
LI Jin-long
SHI Huai-yin
Abstract：Objective To explore the clinicopathologic characteristics and prognosis states of undifferentiated thyroid carcinomas(UTC).Methods Clinicopathologic data of poorly differentiated carcinomas were collected and patients with UTC were visited.The final follow-up deadline was April 16,2023.Results There were 32 female patients(61.5％)and 20 male patients(38.5％),and their average age was 62.7 years.Spindle-shaped cell tumor was dominant,and 40.4％of patients were accompanied by papillary thyroid carcinoma(PTC),follicular carcinoma and squamous-cell carcinoma(21/52).In terms of immunohistochemistry(IHC),vimentin had an expression rate at 95.2％;37.5％of SMA was partially positive;p53+(64.3％);TTF-1,TG and PAX-8 were positive at a low rate and epithelial markers were mostly positive,and the mean Ki67 proliferation index was 50％.Compared with the UTC group without follicular carcinoma,the maximum diameter of the UTC with follicular carcinoma was larger(r=0.599,P=0.005),and its overall survival/cancer-specific survival(OS/CSS)was shorter(4.29±1.21 m vs.55.06±17.68 m,P=0.028).After comparing with the UTC group with unmerged PTC,the probability of recurrency in a partial scope of 9 patients with PTC components in the UTC group was higher(33.3％vs.4.7％,P=0.031),and the total survival time was longer(85.95±38.20 m vs.16.54±5.26 m,P=0.057).Patients with a history of smoking had a shorter overall survival time.The overall survival rates of the UTC group were that the semi-annual survival rate was in the range of 45.0±9.0％,the one-year survival rate was in the range of 33.0±8.0％,the two-year survival rate was in the range of 23.0±8.0％,and the five-year and ten-year survival rates were in the range of 19.0±7.0％.Conclusion The UTC prognosis state is poor,that with follicular carcinoma is worse,and that with PTC might be better.More commonly,UTC might be derived from follicular carcinoma.
Keywords：Undifferentiated thyroid carcinomas/anaplastic thyroid carcinomaClinicopathologic characteristicsPrognosis
Publication Date：2023-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 867-871 )