Usefulness of abnormal HER-2 in patients with non-small cell lung cancer
WANG Mu-sen
GUO Ye-bing
GAO Fei
ZHANG Hong-kai
Abstract：Objective To investigate the meaning of abnormal HER-2 expression and/or mutaion in patients with non-small cell lung cancer.Methods We analyzed the histopathology,immunohistochemitry,fluorescence in situ hybridization(FISH)and gene detection(amplification block mutation system ARMS method)in 183 patientswith NSCLC in Donge County People's Hospital.Results There was a statistically significant correlation between HER-2 gene mutation and the age(＜55 years old)(P＜0.001),but no statistically significant correlation between HER-2 gene mutation and other clinicopathologic features.There was no significant correlation between HER-2 protein expression,gene amplification and clinicopathological features.There was also no significant correlation between HER-2 protein expression and gene amplification status and non-small cell lung cancer 9 gene(EGFR,ALK,KRAS,HER-2,PIK3CA,RET,BRAF,NRAS,ROS1)mutation.Conclusion HER-2 point mutation is correlated with the age of NSCLC patients,but not with other clinicopathologic features.The meaning of HER-2 abnormal status needs more studies.
Keywords：Human epidermal growth factor receptor-2Non-small cell lung cancerClinicopathological featuresLung cancer 9 genesGene detection
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 762-766 )