Molecular classification and clinicopathological features of endometrial carcinoma
TIAN Liang
LIU Yan
WANG Chun-lou
YANG Mo
WANG Su-ling
MIAO Zhi-gang
AN Li-juan
Abstract：Objective To investigate the molecular classification and clinical case characteristics of endometrial cancer.Methods Forty-six cases of endometrial cancer underwent surgical treatment in Cangzhou Central Hospital were collected using immunohistochemistry and Sanger sequencing.According to the method recommended by WHO,the molecular typing was carried out,and the clinicopathological characteristics of each subgroup were analyzed.Results A total of 46 cases of endometrial cancer were included,Among them,there were 41 cases of endometrioid adenocarcinoma,4 cases of serous carcinoma,and 1 case of dedifferentiated endometrial carcinoma.The 2 cases of POLEmut both had exon9 mutation:c.857C＞G(P.P286R),and 1 case had abnormal p53.Among the 20 cases of MMRd subtype,15 cases of simultaneous deletion of MLH1/PMS2 were all caused by methylation of MLH1 promoter.Among the 4 cases of p53abn subtype,the expression pattern of missense mutation was dominant.The NSMP subtypes were all endometrioid adenocarcinomas.Conclusion By analyzing the histological characteristics of each molecular subgroup,tumor morphology can provide clues to the molecular classification of endometrial cancer.In the future,only by combining clinicopathological factors with molecular classification can we provide an important basis for clinical prognosis assessment.
Keywords：Uterine neoplasmsMolecular classificationEndometrial cancer
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 757-761 )