Angiomatous fibrous histiocytoma:a clinicopathological analysis of five cases
ZHAO Yang
WU Ning-qi
SHU Li-shan
WU-Qiong
OU Yu-rong
Abstract：Objective To investigate the clinicopathological features,immunophenotype,differential diagnosis and relationship with PD-L1 of angiomatoid fibrous histiocytoma(AFH).Methods The clinicopathological features,immunophenotype and PD-L1 expression of five cases of AFH were retrospectively analyzed,and the relevant literature was reviewed.Results There were 1 male patient and 4 female patients,aged from 2 to 65 years.The clinical presentation was a subcutaneous painless mass.Grossly,tumor size was 0.8～3.0 cm,section was gray white gray red.Microscopically,nodular growth of tumor cells,fibrous envelope and pseudo-vascular-like space formation,lymphocyte and plasma cell infiltration around the tumor.Immunophenotypically,Vimentin,Desmin,CD68,SMA,CD99 and EMA were positive,while CD34 and S-100 were negative.PD-L1 was positively expressed in 3 cases.Conclusion AFH is a rare intermediate tumor,and its diagnosis is mainly based on pathological features,immunohistochemical and molecular detection.PD-L1 can be expressed in AFH,providing a basis for a new treatment plan for patients with AFH.
Keywords：Angiomatous fibrous histiocytomaPathological featuresImmunohistochemistryPD-L1
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 752-756 )