Clinicopathologic features of inclusion body fibromatosis
ZHANG Lei
GUO Fang-fang
WEI Jian-guo
LUO Rong-kui
LI Sheng-lei
Abstract：Purpose To summarize the clinicopathologic features, special stain, immunophenotype, diagnosis and differential diagnosis of inclusion body fibromatosis (IBF). Methods Five cases of IBF were included. The clinicopathological features, immunohistochemical findings and follow-up data were evaluated. Results The patients aged from 4 to 24 months. Three cases were male and two were female. The average age was 10.6 months. Three cases accured in the toes and two cases were fingers. One case revealed a recurrent disease, showing three small nodules in the right ring finger and the small finger. The lesions were small, solid, and covered with skin. Histology showed fibroblast proliferation with multiple collagen fibers in dermal and subcutaneous. The most characteristic pathological changes were the eosinophilic inclusions in the cytoplasm of spindle fibroblasts. The Masson staining of inclusion body was dark red. The tumor cells were positive for SMA, desmin and calponin. Conclusions IBF is a rare benign myofibroblast tumor, and the most characteristic pathological changes were the eosinophilic inclusions in the cytoplasm of spindle fibroblasts. IBF has the potential of local recurrence, and enlargement resection is the best treatment.
Keywords：Inclusion body fibromatosisFibromatosisInfancyPathology
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 451-453,459 )