Clinicopathologic features of epithelioid angiomyolipomas: an analysis of 16 cases
ZHANG Yu
HUO Yuan-yuan
ZHANG Tao-tao
JING Cai-ping
ZHAO Xue-yan
LIU Rui-yan
LI Gen
ZHANG Guan-jun
Abstract：Purpose To discuss the clinicopathologic features, diagnosis, differential diagnosis and prognosis of epithelioid angiomyolipoma (EAML) and to improve understanding of EAML. Methods Retrospective analyses of the clinical features, pathological morphology and immunohistochemistry were conducted in 16 cases of epithelioid angiomyolipoma. Results Of the sixteen cases, there were 4 males and 12 females; the average age was 34 years. There were 6 cases that the imaging showed hamartoma, while the other ten were considered as malignant lesions. Histologically, the tumors were predominantly composed of epithelioid cells, and one case with a tumor thrombus extended into the renal vein and IVC, four cases with hemorrhage and cystic degeneration. Immunohistochemically, the epithelioid cells all were strongly positive for HMB45, SMA and vimentin, 14 were positive for Melan A, while EMA and CK protein were negative. There were 14 cases with complete follow-up data for 14-75 months after operation; one case was found recurrence, while the other cases were without metastasis. Conclusions EAML is a rare mesenchymal tumor with malignant potential, clinicians would be easily misdiagnosed as malignant tumors. Identified diagnosis depends on pathological examination, especially immunohistochemistry. Since EAML has a possibility of recurrence and metastasis, a close follow-up would be beneficial after surgery.
Keywords：Epithelioid angiomyolipomaClinicopathologic featuresImmunohistochemistryDiagnosis and differential diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 439-443 )