Phosphaturic mesenchymal tumor originated from central nerve system
LI Yuan
LI Zhi-yuan
ZHONG Ding-rong
Abstract：Objective To study the clinical and pathological features of phosphaturic mesenchymal tumor (PMT) which originated from central nerve system (CNS). Methods We reported two cases with reviewing clinical, radiological and pathological features. Immunohistochemical staining was performed. Results 2 cases were women, 68 and 56 year old, arising from right side of the olfactory ditch and 11th thoracic spinal canal. Microscopically, the tumor cells were spindle shaped or stellate, scattered small mature fat cells, cloud like calcification and ossification were identified. The tumor was rich in small vessels, and thick walled blood vessels also. Mitotic figure was rare. Immunohistochemically, tumor cells expressed FGF23, Vimentin, CD56 and NSE; focally expressed CD99 and Bcl-2; EMA, GFAP and CD34 were negative; Ki-67 index was < 5％. Conclusion PMT originated from CNS is very rare, which has specific clinicopathologic features and should be distinguished from meningioma. Complete surgical resection is curative, and otherwise it may reoccur. Radiology is suggestive of effective.
Keywords：Tumor-induced osteomalaciaPhosphaturic mesenchymal tumorCentral nerve systemDifferential diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 401-405 )