Clinicopathologic features of atypical carcinoid combined with adenocarcinoma in situ of uterine cervix
MING Jian
XU Bin
XIN Xiao-chuan
FANG Wan-ting
JIANG Yan-duo
Abstract：Objective To study the clinicopathological features,diagnosis,and differential diagnosis of atypical carcinoid combined with adenocarcinoma in situ (AIS) of the uterine cervix.Methods A case of atypical carcinoid combined with AIS in the uterine cervix was investigated by clinical findings,histopathology and immunohistochemistry,and related literatures were reviewed.Results A 46-year-old woman presented with vaginal bleeding for 6 months.MRI examination showed an uterine cervical mass.The patient was treated with hysterectomy,bilateral salpingoophorectomy and lymphadenectomy.Microscopic examination revealed that the tumor contained two kinds of histological morphology,atypical carcinoid and AIS,which grew independently.Immunohistochemically,CK,CD56,Syn and CDll7 were positive in neuroendocrine tumor,while AIS was positive for CK,CEA,pl6 and CDX2.Conclusions Atypical carcinoid combined with AIS of the uterine cervix is rare.Differential diagnosis of atypical carcinoid includes poorly-differentiated adenocarcinoma,carcinoid,large cell neuroendocrine tumor,adenoid basal carcinoma and secondary atypical carcinoid.
Keywords：Uterine cervixAtypical carcinoidAISClinicopathologic features
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 340-344 )