Endometrial stromal sarcoma: immunophenotype and genetic characteristics
ZHANG Xiao-ling
ZHANG Xiao-bo
WANG Gong-wei
WANG Ying
LIU Li-li
WANG Xing-xing
SHEN Danhua
Abstract：To summarize the pathological characteristics,immunophenotype of endometrial stromal sarcoma (ESS) and to explore the significance of YWHAE-NUTM2A/B fusion gene in ESS.Method 28 cases of ESS were studied,including 21 cases of low-grade ESS and 7 cases of high-grade ESS.Immunohistochemical method (IHC) was used to detect estrogen receptor (ER) and progesterone receptor (PR),CD10,cyclin D1,Desmin and caldesmon expression in 28 cases of ESS.Fluorescence in situ hybridization (FISH) was used to detect the expression of YWHAE-NUTM2A/B gene fusion.Results The positive rate of ER,PR,CD10,cyclin D1,Desmin and caldesmon in low-grade ESS was 19/21,20/21,21/21,0/21,7/21,3/21,respectively and the rate in high-grade ESS was 2/7,2/7,5/7,7/7,0/7,1/7.The positive rate of the YWHAE-NUTM2A/B fusion gene was 3/7.Conclusion low-grade ESS has special morphological characteristics,and is associated with biomarkers of the endometrial stromal sarcoma,high-grade ESS has the similar immunohistochemical characteristics to the low-grade ESS.FISH has a certain significance in the diagonosis of the highgrade ESS.
Keywords：Endometrial stromal tumorsFISHYWHAE2A/BImmunohistochemistry
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 330-334 )